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For research use only.
Background | This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor chemokine (C-C motif) receptor 5 (CCR5), and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. Alternative splicing results in multiple transcript variants that encode different isoforms. |
Synonyms | CCL5, D17S136E, SCYA5 |
Swissprot | |
Reactivity | Human |
Specificity | Detects Human RANTES in ELISAs |
Applications | ELISA |
Storage | -20℃ |
Expiration date | 12 months |
Introduction | This Antibody Pair Kit applies to the sandwich ELISA assay. |
Other Clones
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Other Formats
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Biotin
