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For research use only.
| Background | Programmed cell death ligand 1 ( CD274;or B7-H1;PD-L1 ) ;is the first member of B7 family to be discovered. B7 family molecules are type I transmembrane proteins belonging to the immunoglobulin superfamily. In concert with their CD28 family receptors;the B7s are key regulators of the adaptive immune response. CD274 is suggested a negative regulator of T and B cell;and play important role in mediating tolerance of lymphocytes to self-antigens. It also involved in the costimulatory signal;essential for T-cell proliferation and production of IL10 and IFNG;in an IL2-dependent and a PDCD1-independent manner. PD-L1 is a 290 aa transmembrane protein with a calculated molecular weight of 33 kDa;the apparent molecular weight has been reported as 45-70 kDa;suggesting probable glycosylation . |
| Synonyms | CD274, B7-H1, PD-L1, PDCD1L1, PDL1, B7 homolog 1 |
| Swissprot | |
| Reactivity | Human |
| Specificity | Detects Human PD-L1 in ELISAs |
| Applications | ELISA |
| Storage | -20℃ |
| Expiration date | 12 months |
Other Clones
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Other Formats
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