Human PD-L1 Antibody Pair Set (E-KAB-0463)
For research use only.
| Background |
Programmed cell death ligand 1 ( CD274;or B7-H1;PD-L1 ) ;is the first member of B7 family to be discovered. B7 family molecules are type I transmembrane proteins belonging to the immunoglobulin superfamily. In concert with their CD28 family receptors;the B7s are key regulators of the adaptive immune response. CD274 is suggested a negative regulator of T and B cell;and play important role in mediating tolerance of lymphocytes to self-antigens. It also involved in the costimulatory signal;essential for T-cell proliferation and production of IL10 and IFNG;in an IL2-dependent and a PDCD1-independent manner. PD-L1 is a 290 aa transmembrane protein with a calculated molecular weight of 33 kDa;the apparent molecular weight has been reported as 45-70 kDa;suggesting probable glycosylation .
|
| Synonyms |
CD274, B7-H1, PD-L1, PDCD1L1, PDL1, B7 homolog 1
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| Swissprot | |
| Reactivity |
Human
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| Specificity |
Detects Human PD-L1 in ELISAs
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| Applications |
ELISA
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| Storage |
-20℃
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| Expiration date |
12 months
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Other Clones
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