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For research use only.
| Background | SPARC,also known as ON (Osteonectin) or BM-40 (Basement-membrane protein 40),is an extracellular glycoprotein with the calculated molecular mass of 35 kDa and the apparent molecular mass of 40-43 kDa and 50 kDa . SPARC belongs to a group of matricellular proteins defined as secreted components that do not contribute directly to the formation of structural elements but serve to modulate cell-matrix interactions and cellular functions . SPARC is expressed at high levels in bone tissue,is distributed widely in many other tissues and cell types,and is associated generally with tissues undergoing morphogenesis,remodeling and wound repair . It elicits changes in cell shape,inhibits cell-cycle progression,and influences the synthesis of extracellular matrix . Altered expression of SPARC has been reported in a variety of cancers,which include breast,ovarian,colorectal,and pancreatic cancer as well as melanoma and glioblastomas . |
| Synonyms | SPARC, BM-40, OI17, Osteonectin, acidic, cysteine-rich, Basement-membrane protein 40, Oncysteine-rich protein, Secreted protein acidic and rich in cysteine, secreted protein, ON |
| Swissprot | |
| Reactivity | Human |
| Specificity | Detects Human ON in ELISAs |
| Applications | ELISA |
| Storage | -20℃ |
| Expiration date | 12 months |
| Introduction | This Antibody Pair Kit applies to the sandwich ELISA assay. |
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Biotin
