Human IL-23 Antibody Pair Set (E-KAB-0464)
For research use only.
| Background |
Interleukin-12 ( IL-12 ) ;is a cytokine that is secreted by activated phagocytes and dendritic cells and that induces interferon-γproduction by natural-killer and T lymphocytes. IL-12 is a 75 kDa heterodimer composed of a 35 kDa subunit ( IL-12A p35 ) and a 40 kDa subunit ( IL-12B p40 ) that is secreted by a wide variety of antigen presenting cells ( APCs ) ;including phagocytes;B cells and Langerhans cells. IL-12B has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of IL-12B was observed in the central nervous system of patients with multiple sclerosis ( MS ) ;suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of IL-12B has been reported to be associated with the severity of atopic and non-atopic asthma in children.
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| Synonyms |
IL-23A, IL23P19, P19, SGRF
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| Swissprot | |
| Reactivity |
Human
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| Specificity |
Detects Human IL-23 in ELISAs
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| Applications |
ELISA
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| Storage |
-20℃
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| Expiration date |
12 months
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Other Clones
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