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For research use only.
| Background | Pro-inflammatory cytokine primarily involved in epithelial barrier repair,polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses.Upon binding to IL18R1 and IL18RAP,forms a signaling ternary complex which activates NF-kappa-B,triggering synthesis of inflammatory mediators.Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells and natural killer (NK) cells.Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore. |
| Synonyms | IL18, IGIF, IL-18, IL-1g, IL1F4 |
| Swissprot | |
| Reactivity | Human |
| Specificity | Detects Human IL-18 in ELISAs |
| Applications | ELISA |
| Storage | -20℃ |
| Expiration date | 12 months |
| Introduction | This Antibody Pair Kit applies to the sandwich ELISA assay. |
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Biotin
