Human EGFR2 Antibody Pair Set (E-KAB-0458)
For research use only.
| Background |
Protein tyrosine kinase that is part of several cell surface receptor complexes , but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex , although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules ( MTs ) . Upon ERBB2 activation , the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2 , allowing its association with the cell membrane. In turn , membrane-bound APC allows the localization of MACF1 to the cell membrane , which is required for microtubule capture and stabilization.In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A , the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth.
|
| Synonyms |
ERBB2, HER2, CD340, p185, MLN 19, NEU
|
| Swissprot | |
| Reactivity |
Human
|
| Specificity |
Detects Human EGFR2 in ELISAs
|
| Applications |
ELISA
|
| Storage |
-20℃
|
| Expiration date |
12 months
|
Other Clones
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