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| Background | Aβ derives from APP via proteolytic cleavage by proteases called α- , β- and γ-secretase. The α-secretase cleavage precludes the formation of Aβ , while the β- and γ-cleavages generate APP components with amyloidogenic features. Amyloid beta A4 precursor protein ( APP ) , encoded by APP gene which locate on human chromosome 21q , is a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth , neuronal adhesion and axonogenesis. APP expressed in all fetal tissues and is pronounced in brain , kidney , heart and spleen , but weak in liver. Defects in APP are the cause of Alzheimer disease type 1 ( AD1 ) . This antibody can recogniaze the N-terminus of human APP: Soluble APP-alpha and Soluble APP-beta. |
| Synonyms | Abeta 40, amyloid beta 40, Beta-amyloid protein 40, Aβ ( 1-40 ), Aβ40, Amyloid Beta 40 |
| Swissprot | |
| Reactivity | Human |
| Specificity | Detects Human Aβ1-40 in ELISAs |
| Applications | ELISA |
| Storage | -20℃ |
| Expiration date | 12 months |
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