HSD11B2 Polyclonal Antibody (E-AB-13311)
For research use only.
| Verified Samples |
Verified Samples in IHC: Human liver cancer, Human prostate cancer |
| Dilution | IHC 1:50-1:200 |
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human |
| Applications | IHC |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide of human HSD11B2 |
| Abbre | HSD11B2 |
| Synonyms | 11 DH2, 11 beta HSD2, 11 beta hydroxysteroid dehydrogenase type 2, 11-DH2, 11-beta-HSD2, 11-beta-hydroxysteroid dehydrogenase type 2, AME, AME1, Corticosteroid 11 beta dehydrogenase isozyme 2, Corticosteroid 11-beta-dehydrogenase isozyme 2, DHI2, HSD11B2, HSD11K, HSD2 |
| Swissprot | |
| Cellular Localization | Microsome. Endoplasmic reticulum. |
| Concentration | 0.6 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Cancer, Cell Biology, Cardiovascular, Metabolism, Signal Transduction |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
| background | There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone.The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities.The type II isozyme, encoded by this gene, has only 11-beta-dehydrogenase activity.In aldosterone-selective epithelial tissues such as the kidney, the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor. |
Other Clones
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Other Formats
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Unconjugated
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