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For research use only.
| Host | Rabbit |
| Reactivity | Human |
| Applications | IHC-P |
| Synonyms | Her-2 |
| Cellular Localization | cell membrane |
| Tissue Specificity | Breast cancer |
| Storage | The RTU should be stored at 2~8°C protecting from light (Do not freeze),Valid for 12 months. |
| Shipping | Ice bag |
| background | HER2 (also known as HER2 / neu, C-erbB2, erbB2 or neu) is a transmembrane receptor tyrosine kinase, which is a carcinogenic gene. Its activation will cause malignant transformation and increase the malignant potential of cells (cell proliferation, invasion, etc.). HER-2 is over expressed in 15-25% of primary breast cancer. HER-2 can also be found in gastrointestinal cancer, gastroesophageal cancer, ovarian cancer, well differentiated endometrial cancer and some salivary duct tumors. HER2-expressed breast cancer is usually associated with estrogen and progesterone receptor negative. Therefore, the poor prognosis is related to the expression of HER2. |
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