GRAP Polyclonal Antibody (E-AB-18391)
For research use only.
| Verified Samples |
Verified Samples in IHC: Human gastric cancer, Human breast cancer |
| Dilution | IHC 1:30-1:150 |
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Applications | IHC |
| Clonality | Polyclonal |
| Immunogen | Full length fusion protein |
| Abbre | GRAP |
| Synonyms | GRAP, GRB2 related adaptor protein, GRB2-related adapter protein, Grap, Growth factor receptor bound protein 2 related adaptor protein, MGC64880, OTTHUMP00000065766 |
| Swissprot | |
| Cellular Localization | Cytosol, Plasma Membrane, extrinsic component of cytoplasmic side of plasma membrane, Other locations: cytoplasm. |
| Concentration | 0.7 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Antigen affinity purification |
| Research Areas | Signal Transduction |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
| background | This gene encodes a member of the GRB2/Sem5/Drk family and functions as a cytoplasmic signaling protein which contains an SH2 domain flanked by two SH3 domains. The SH2 domain interacts with ligand-activated receptors for stem cell factor and erythropoietin, and facilitates the formation of a stable complex with the BCR-ABL oncoprotein. This protein also associates with the Ras guanine nucleotide exchange factor SOS1 (son of sevenless homolog 1) through its N-terminal SH3 domain. In general, it couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway. |
Other Clones
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Other Formats
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Unconjugated
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