GPX4 Monoclonal Antibody (AN200085P)
For research use only.
| Verified Samples | Verified Samples in IF: HeLa |
| Dilution | ICC/IF 1:100-1:400, |
| Isotype | IgG1 |
| Host | Mouse |
| Reactivity | Human |
| Applications | ICC/IF |
| Clonality | Monoclonal |
| Immunogen | Recombinant Human GPX4 Protein |
| Abbre | GPX4 |
| Synonyms | glutathione peroxidase, GSHPx, GPx, GPX4, GPx-4, GSHPx-4, MCSP, PHGPx, SMDS, snGPx, snPHGPx, glutathione peroxidase 4, glutathione peroxidase 4, GPx-4, GSHPx-4, MCSP, PHGPx, SMDS, snGPx, snPHGPx |
| Swissprot | |
| Cellular Localization | Mitochondrion, Cytoplasm. |
| Concentration | 1 mg/mL |
| Buffer | 0.2 μm filtered solution in PBS |
| Purification Method | Protein A |
| Research Areas | Signal Transduction, Cancer, Metabolism |
| Clone No. | 5H2 |
| Conjugation | Unconjugated |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
| Shipping | Ice bag |
| background | The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of hydrogen peroxide, organic hydroperoxides and lipid hydroperoxides, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme has a high preference for lipid hydroperoxides and protects cells against membrane lipid peroxidation and cell death. It is also required for normal sperm development; thus, it has been identified as a 'moonlighting' protein because of its ability to serve dual functions as a peroxidase, as well as a structural protein in mature spermatozoa. Mutations in this gene are associated with Sedaghatian type of spondylometaphyseal dysplasia (SMDS). This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. |
Other Clones
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Other Formats
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Unconjugated
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