GluR2 Polyclonal Antibody (E-AB-12603)
For research use only.
| Verified Samples |
Verified Samples in IHC: Human breast cancer, Human gastric cancer |
| Dilution | IHC 1:25-1:100 |
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Applications | IHC |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide of human GRIA2 |
| Abbre | GluR2 |
| Synonyms | AMPA 2, AMPA selective glutamate receptor 2, AMPA-selective glutamate receptor 2, AMPA2, GLUR 2, GLUR B, GLUR2, GLURB, GRIA2, GluA2, GluR K2, GluR-2, GluR-B, GluR-K2, Glutamate receptor 2, Glutamate receptor ionotropic, Glutamate receptor ionotropic AMPA 2, Gria2, HBGR2 |
| Swissprot | |
| Cellular Localization | Cell membrane. Endoplasmic reticulum membrane. Cell junction>synapse>postsynaptic cell membrane. Interaction with CACNG2, CNIH2 and CNIH3 promotes cell surface expression. |
| Concentration | 0.4 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Cancer, Neuroscience |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
| background | Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, GRIA1-4. The subunit encoded by this gene (GRIA2) is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Human and animal studies suggest that pre-mRNA editing is essential for brain function, and defective GRIA2 RNA editing at the Q/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology. Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene. |
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Unconjugated
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