GAD1 Polyclonal Antibody (E-AB-17390)
For research use only.
| Verified Samples |
Verified Samples in WB: Mouse brain Verified Samples in IHC: Human breast cancer |
| Dilution | WB 1:200-1000, IHC 1:25-100 |
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide of human GAD1 |
| Abbre | GAD1 |
| Synonyms | 67 kDa glutamic acid decarboxylase, 67kDa), CPSQ1, DCE1, EC 4.1.1.15, FLJ45882, GAD, GAD 67, GAD-67, GAD1, Glutamate decarboxy, Glutamate decarboxylase 1, Glutamate decarboxylase 1 (brain, Glutamate decarboxylase 1 brain 67kD, Glutamate decarboxylase 1 brain 67kDa |
| Swissprot | |
| Calculated MW | 67 kDa |
| Cellular Localization | Mitochondrion, Plasma Membrane, Other locations: axon, axon terminus, cell cortex, clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane, inhibitory synapse, intracellular, presynaptic active zone, vesicle membrane. |
| Concentration | 0.2 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Cancer, Metabolism, Immunology, Signal transduction |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
| background | This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes.The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid.A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes.This gene may also play a role in the stiff man syndrome.Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures.Alternative splicing of this gene results in two products, the predominant 67-kD form and a less-frequent 25-kD form. |
Other Clones
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Other Formats
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Unconjugated
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