FLNB Polyclonal Antibody (E-AB-62747)
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For research use only.
| Verified Samples |
Verified Samples in IHC: Rat heart, Human liver damage, Human prostate Verified Samples in IF: HeLa, HUVEC, NIH/3T3, PC12 |
| Dilution | IHC 1:50-1:100, IF 1:20-1:100 |
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Applications | IHC, IF |
| Clonality | Polyclonal |
| Immunogen | Recombinant fusion protein of human FLNB (NP_001157789.1). |
| Abbre | FLNB |
| Synonyms | ABP-278, ABP-280, AOI, FH1, FLN-B, FLN1L, FLNB, LRS1, SCT, TABP, TAP, filamin-B |
| Swissprot | |
| Cellular Localization | Cytoplasm, cytoskeleton, Polarized at the periphery of myotubes, Cytoplasm, cytoskeleton, Predominantly localized at actin stress fibers and Cytoplasm, cell cortex, Cytoplasm, cytoskeleton, Cytoplasm, myofibril, sarcomere, Z line, In differentiating myotubes, isoform 1, isoform 2 and isoform 3 are localized diffusely throughout the cytoplasm with regions of enrichment at the longitudinal actin stress fiber, In differentiated tubes, isoform 1 is also detected within the Z-lines. |
| Concentration | 1 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Signal Transduction |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
| background | This gene encodes a member of the filamin family. The encoded protein interacts with glycoprotein Ib alpha as part of the process to repair vascular injuries. The platelet glycoprotein Ib complex includes glycoprotein Ib alpha, and it binds the actin cytoskeleton. Mutations in this gene have been found in several conditions: atelosteogenesis type 1 and type 3; boomerang dysplasia; autosomal dominant Larsen syndrome; and spondylocarpotarsal synostosis syndrome. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. |
Other Clones
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Other Formats
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Unconjugated
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