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For research use only.
| Alternate Names | IPEXJM2ScurfinZinc finger protein JM2, Forkhead box protein P3 |
| Clone No | |
| Leadtime | Order now, ship in 3 days |
| Background | FOXP3 is a 47 kD transcription factor, also known as Forkhead box protein P3, Scurfin, JM2, or IPEX. It is proposed to be a master regulatory gene and more specific marker of T regulatory cells than most cell surface markers (such as CD4 and CD25). Transduced expression of FOXP3 in CD4<sup>+</sup>/CD25<sup>-</sup> cells has been shown to induce GITR, CD103, and CTLA4 and impart a T regulatory cell phenotype. FOXP3 is mutated in X-linked autoimmunity-allergic dysregulation syndrome (XLAAD or IPEX) in humans and in "scurfy" mice. Overexpression of FOXP3 has been shown to lead to a hypoactive immune state suggesting that this transcriptional factor is a central regulator of T cell activity. |
| Abbre | Foxp3 |
| Swissprot | |
| Host | Rat |
| Reactivity | Mouse;Rat |
| Clonality | Monoclonal |
| Isotype | Rat IgG2a, κ |
| Isotype Control | E-AB-F09832C |
| Applications | ICFCM |
| Research Areas | Immunology |
| Cellular Localization | Nucleus;Cytoplasm |
| Form | Liquid |
| Conjugation | FITC |
| Conjugation Information | FITC is designed to be excited by the Blue laser (488 nm) and detected using an optical filter centered near 530 nm (e.g., a 525/40 nm bandpass filter). |
| Spectrum | |
| Storage Buffer | Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant. |
| Storage | This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze. |
| Expiration Date | 12 months |
| Shipping | Ice bag |
Other Clones
1 Results
Other Formats
1 Results
APC
Elab Fluor®700
FITC
PE
PE/Cyanine 5
PE/Elab Fluor®594
PerCP/Cyanine 5.5
Unconjugated
