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For research use only.
| Alternate Names | CTLA-8, CTLA8, Cytotoxic T-lymphocyte-associated antigen 8, IL-17, IL-17A, Interleukin-17A |
| Clone No | |
| Leadtime | Order now, ship in 3 days |
| Background | IL-17, also known as CTLA-8, is a T cell-expressed pleiotropic cytokine that exhibits a high degree of homology to a protein encoded by the ORF13 gene of herpes virus Saimiri. IL-17 is produced by Th cells (Th17) that are distinct from the traditional Th1- and Th2-cell subsets. IL-23 plays an important role in triggering IL-17 production. Both recombinant and natural IL-17 have been shown to exist as disulfide linked homodimers. IL-17 exhibits multiple biological activities on a variety of cells including: the induction of IL-6 and IL-8 production in fibroblasts, activation of NF-κB, and costimulation of T cell proliferation. IL-17 is an essential inflammatory mediator in the development of autoimmune diseases. Neutralization of IL-17 with monoclonal antibody is able to ameliorate the disease course. |
| Abbre | IL-17A |
| Swissprot | |
| Host | Rat |
| Reactivity | Mouse |
| Clonality | Monoclonal |
| Isotype | Rat IgG1, κ |
| Isotype Control | E-AB-F09822C |
| Applications | ICFCM |
| Research Areas | Cell Biology;Immunology;Neuroinflammation;Neuroscience |
| Cellular Localization | Secreted |
| Form | Liquid |
| Concentration | 5 μL/Test |
| Conjugation | FITC |
| Conjugation Information | FITC is designed to be excited by the Blue laser (488 nm) and detected using an optical filter centered near 530 nm (e.g., a 525/40 nm bandpass filter). |
| Spectrum | |
| Storage Buffer | Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant. |
| Storage | This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze. |
| Expiration Date | 12 months |
| Shipping | Ice bag |
Other Clones
1 Results
Other Formats
1 Results
APC
Biotin
Elab Fluor®647
Elab Fluor®700
Elab Fluor®Violet 450
FITC
None (AF/LE)
None (AF/LE)
PE
PE/Cyanine 7
Unconjugated
