ERBB2 Polyclonal Antibody (E-AB-53244)
For research use only.
| Verified Samples |
Verified Samples in IHC: Human colorectal cancer |
| Dilution | IHC 1:50-1:100 |
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Applications | IHC |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide of human ERBB2 |
| Abbre | ERBB2 |
| Synonyms | C erb B2/neu protein, CD340, CD340 antigen, Cerb B2/neu protein, CerbB2, ERBB2, Erb b2 receptor tyrosine kinase 2, HER 2, HER 2/NEU, HER2, Herstatin, Human epi, Verb b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog |
| Swissprot | |
| Cellular Localization | Cytoplasm. Nucleus and Cell membrane. Cytoplasm, perinuclear region. Nucleus. Translocation to the nucleus requires endocytosis, probably endosomal sorting and is mediated by importin beta-1/KPNB1. |
| Concentration | 1.68 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Antigen affinity purification |
| Research Areas | Cancer, Immunology, Signal Transduction, Tags and Cell Markers |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
| background | HER2,also known as ErbB2 and Neu,is a 185-kDa transmembrane glycoprotein that is a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. It has no ligand binding domain of its own and therefore cannot bind growth factors. However,it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer,stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways,such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Amplification and/or overexpression of HER2 have been reported in numerous cancers,including breast and ovarian tumors. HER2 is a therapeutic target for the treatment of breast cancer and other carcinomas. |
Other Clones
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Other Formats
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Unconjugated
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