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For research use only.

Verified Samples Verified Samples in IHC: Human tonsil
Dilution IHC 1:35-1:200
Isotype IgG
Host Rabbit
Reactivity Human
Applications IHC
Clonality Polyclonal
Immunogen Full length fusion protein
Abbre EDARADD
Synonyms Cr,  Crinkled homolog,  ED3,  EDA3,  EDAD,  EDAR associated death domain,  EDAR-associated death domain protein,  EDARADD,  Ectodysplasin-A receptor-associated adapter protein,  Protein crinkled homolog,  ectodysplasia A receptor associated death domain
Swissprot
Cellular Localization Cytoplasm.
Concentration 0.9 mg/mL
Buffer Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
Purification Method Antigen affinity purification
Research Areas Epigenetics and Nuclear Signaling,  Developmental biology,  Signal transduction
Conjugation Unconjugated
Storage Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Shipping The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.
background This gene was identified by its association with ectodermal dysplasia, a genetic disorder characterized by defective development of hair, teeth, and eccrine sweat glands.The protein encoded by this gene is a death domain-containing protein, and is found to interact with EDAR, a death domain receptor known to be required for the development of hair, teeth and other ectodermal derivatives.This protein and EDAR are coexpressed in epithelial cells during the formation of hair follicles and teeth.Through its interaction with EDAR, this protein acts as an adaptor, and links the receptor to downstream signaling pathways.Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
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Unconjugated

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