DNASE1 Polyclonal Antibody (E-AB-66303)
For research use only.
| Verified Samples |
Verified Samples in IF: C6, NIH/3T3 |
| Dilution | IF 1:50-1:200 |
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Mouse, Rat |
| Applications | IF |
| Clonality | Polyclonal |
| Immunogen | Recombinant fusion protein of human DNASE1 (NP_005214.2). |
| Abbre | DNASE1 |
| Synonyms | DNASE1, DNL1, DRNI |
| Swissprot | |
| Cellular Localization | Secreted. Nucleus envelope. Secretory protein, stored in zymogen granules and found in the nuclear envelope. |
| Concentration | 1 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Cancer, Cell Biology, Epigenetics and Nuclear Signaling, Metabolism |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
| background | This gene encodes a member of the DNase family. This protein is stored in the zymogen granules of the nuclear envelope and functions by cleaving DNA in an endonucleolytic manner. At least six autosomal codominant alleles have been characterized, DNASE1*1 through DNASE1*6, and the sequence of DNASE1*2 represented in this record. Mutations in this gene have been associated with systemic lupus erythematosus (SLE), an autoimmune disease. A recombinant form of this protein is used to treat the one of the symptoms of cystic fibrosis by hydrolyzing the extracellular DNA in sputum and reducing its viscosity. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. |
Other Clones
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Other Formats
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Unconjugated
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