Cytokeratin 8 Monoclonal Antibody (AN200190P)
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For research use only.
| Verified Samples |
Verified Samples in IHC: Human liver, Human prostate, Human colon carcinoma, Human small intestine Verified Samples in IF: Hela |
| Dilution | IHC-P 1:500-1:5000, ICC/IF 1:20-1:100 |
| Isotype | IgG1 |
| Host | Mouse |
| Reactivity | Human |
| Applications | IHC-P, ICC/IF |
| Clonality | Monoclonal |
| Immunogen | A synthetic peptide corresponding to the C-terminus of the Human Cytokeratin 8 |
| Abbre | KRT8 |
| Synonyms | CYK, KRT, CYK8, KRT8, CARD2, CARD2, CK 8, CK-8, CK8, CYK8, CYKER, Cytokeratin endo A, Cytokeratin-8, DreK8, EndoA, K2C8, K2C8, K8, Keratin 8, Keratin type II cytoskeletal 8, Keratin, type II cytoskeletal 8, Keratin-8, KO, Krt 2.8, KRT8, MGC118110, MGC174782, MGC53564, MGC85764, sb:cb186, Type-II keratin Kb8, CK 8, CK8, CK-8, CYKER, Cytokeratin endo A, Cytokeratin-8, DreK8, EndoA, K2C8, Keratin, Keratin 8, Keratin type II cytoskeletal 8, Keratin-8, Krt 2.8, MGC118110, MGC174782, MGC53564, MGC85764, sb:cb186, type II cytoskeletal 8, Type-II keratin Kb8 |
| Swissprot | |
| Cellular Localization | Cytoplasm, Nucleus, nucleoplasm, Nucleus matrix |
| Tissue Specificity | Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma membrane in structures that contain dystrophin and spectrin. Expressed in gingival mucosa and hard palate of the oral cavity. |
| Concentration | 1 mg/mL |
| Buffer | 0.2 μm filtered solution in PBS |
| Purification Method | Protein A |
| Research Areas | Signal Transduction, Cancer |
| Clone No. | 10F13 |
| Conjugation | Unconjugated |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
| Shipping | Ice bag |
| background | KRT8 (Keratin 8) is a Protein Coding gene. 2 alternatively spliced human isoforms have been reported. This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. KRT8 is the major component of the intermediate filament cytoskeleton and is predominantly expressed in simple epithelial tissues. Aberrant expression of KRT8 is associated with multiple tumor progression and metastasis.KRT8 overexpression in renal cancer cell lines promoted cell migration and invasion. In contrast, KRT8 knockdown suppressed ccRCC metastasis both in vitro and in vivo.KRT8 expression may therefore be a biomarker or potential therapeutic target to identify patients with worse survival. Diseases associated with KRT8 include Liver Cirrhosis and Cryptogenic Cirrhosis. |
Other Clones
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Other Formats
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Unconjugated
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