CTCF Polyclonal Antibody (E-AB-64522)
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For research use only.
| Verified Samples |
Verified Samples in IHC: Rat liver, Rat brain, Rat spleen, Mouse brain Verified Samples in IF: Hela, U-2OS, U2OS |
| Dilution | IHC 1:50-1:200, IF 1:50-1:200 |
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Applications | IHC, IF |
| Clonality | Polyclonal |
| Immunogen | Recombinant fusion protein of human CTCF (NP_006556.1). |
| Abbre | CTCF |
| Synonyms | CTCF, CTCF , MRD21 |
| Swissprot | |
| Cellular Localization | Nucleus, nucleoplasm, Chromosome, Chromosome, centromere, May translocate to the nucleolus upon cell differentiation, Associates with both centromeres and chromosomal arms during metaphase, Associates with the H19 ICR in mitotic chromosomes, May be preferentially excluded from heterochromatin during interphase. |
| Concentration | 1 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Cancer, Epigenetics and Nuclear Signaling |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
| background | This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms' tumors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
Other Clones
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Other Formats
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Unconjugated
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