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For research use only.
| Alternate Names | B7H1PD-L1PDCD1L1PDCD1LG1PDL1, B7 homolog 1, B7-H, B7-H1, Programmed cell death ligand 1 |
| Clone No | |
| Leadtime | Order now, ship in 3 days |
| Background | CD274, also known as B7-H1 or programmed death ligand 1 (PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. It is expressed on T cells, B cells, NK cells, dendritic cells, IFN-γ activated endothelial cells, and monocytes. B7-H1 is one of the ligands of PD-1. The interaction of B7-H1 with PD-1 plays an important role in the inhibition of T cell responses. Other studies have shown that B7-H1 is able to costimulate T cell growth and cytokine production. CD274 is involved in costimulation essential for T cell proliferation and production of IL-10 and IFN-γ, in an IL-2-dependent and a PD-1-independent manner. Its interaction with PD-1 inhibits T cell proliferation and cytokine production. |
| Abbre | CD274 |
| Swissprot | |
| Host | Rat |
| Reactivity | Mouse |
| Clonality | Monoclonal |
| Isotype | Rat IgG2b, κ |
| Isotype Control | E-AB-F09843B |
| Applications | FCM |
| Research Areas | Cancer Biomarkers;Costimulatory Molecules;Immunology |
| Cellular Localization | Membrane |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Conjugation | Biotin |
| Storage Buffer | Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant. |
| Storage | This product can be stored at 2-8°C for 12 months. Do not freeze. |
| Expiration Date | 12 months |
| Shipping | Ice bag |
Other Clones
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Other Formats
1 Results
APC
Biotin
Elab Fluor®488
Elab Fluor®647
Elab Fluor®Violet 450
FITC
PE
Unconjugated
