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Biotin Anti-Mouse CD272/BTLA Antibody[PK18.6] (E-AB-F1024B)

AllSizePriceQty
100μg $ 90.00
25μg $ 36.00
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For research use only.

Alternate NamesB- and T-lymphocyte attenuator,  B- and T-lymphocyte-associated protein,  Btla,  CD272
Clone No
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BackgroundCD272, also known as B and T lymphocyte attenuator (BTLA), is an Ig superfamily co-inhitory receptor with structural similarity to programmed cell death 1 (PD-1) and CTLA-4. BTLA is expressed on B cells, T cells, macrophages, dendritic cells, NKT cells, and NK cells. Engagement of BTLA by its ligand herpes virus entry mediator (HVEM) is critical for negatively regulating immune response. The absence of BTLA with HVEM inhibitory interactions leads to increased experimental autoimmune encephalomyelitis severity, enhanced rejection of partially mismatched allografts, an increased CD8+ memory T cell population, increased severity of colitis, and reduced effectiveness of T regulatory cells. BTLA plays an important role in the induction of peripheral tolerance of both CD4+ and CD8+ T cells in vivo. Tolerant T cells have significantly higher expression of BTLA compared with effectors and naïve T cells. BTLA may cooperate with CTLA-4 and PD-1 to control T cell tolerance and autoimmunity. It was reported that BTLA may regulate T cell function by binding to B7-H4, but further studies are needed to confirm. The existence of three distinct BTLA alleles has been reported.
AbbreCD272
Swissprot
HostRat
ReactivityMouse
ClonalityMonoclonal
Isotype Rat IgG1, κ
Isotype Control E-AB-F09823B
Applications
FCM
Research AreasImmunology;Inhibitory Molecules
Cellular Localization
Membrane
FormLiquid
Concentration
0.5 mg/mL
ConjugationBiotin
Storage BufferPhosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
StorageThis product can be stored at 2-8°C for 12 months. Do not freeze.
Expiration Date12 months
ShippingIce bag
Cat.No. Product Name Sizes
E-CK-A105 10×ACK Lysis Buffer 500mL , 200mL , 100mL
E-CK-A107 Cell Staining Buffer 500mL , 200mL , 100mL
Other Clones

1 Results

    Other Formats

    1 Results

    APC

    Biotin

    Elab Fluor®647

    Elab Fluor®700

    FITC

    PE

    PE/Cyanine 5

    PE/Cyanine 7

    PerCP/Cyanine 5.5

      Product Information