Bcl-XL Monoclonal Antibody (AN200246P)
For research use only.
| Verified Samples | Verified Samples in IHC: Human kidney, Human gallbladder |
| Dilution | IHC-P 1:100-1:1000 |
| Isotype | IgG1 |
| Host | Mouse |
| Reactivity | Human |
| Applications | IHC-P |
| Clonality | Monoclonal |
| Immunogen | E. coli-derived Human Bcl-XL fragment |
| Abbre | BCL2L1 |
| Synonyms | Bcl-2-Like Protein, PPP1R, Bcl2-L, BCL2 like, BCL2L1, BCL-XL/S, BCL2L, BCLX, Bcl-X, PPP1R52, BCL2 like 1, Bcl-XL, Apoptosis Regulator Bcl-X, Bcl2-L-1, Bcl-2-Like Protein 1, BCLXL, BCLXS, bcl-xS, Apoptosis regulator Bcl X, Apoptosis regulator BclX, B cell lymphoma 2 like, B2CL1, Bcl 2 like 1 protein, Bcl X, Bcl xL, BCL XL/S, Bcl xS, Bcl2 related gene, DKFZp781P2092, Protein phosphatase 1 regulatory subunit 52 |
| Swissprot | |
| Tissue Specificity | Bcl-X(S) is expressed at high levels in cells that undergo a high rate of turnover, such as developing lymphocytes. In contrast, Bcl-X(L) is found in tissues containing long-lived postmitotic cells, such as adult brain. |
| Concentration | 1 mg/mL |
| Buffer | 0.2 μm filtered solution in PBS |
| Purification Method | Protein A |
| Research Areas | Cell Biology, Signal Transduction, Cancer, Metabolism |
| Clone No. | 6B9 |
| Conjugation | Unconjugated |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
| Shipping | Ice bag |
| background | The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Alternative splicing results in multiple transcript variants encoding two different isoforms. The longer isoform acts as an apoptotic inhibitor and the shorter isoform acts as an apoptotic activator. |
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Unconjugated
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