ATXN3 Polyclonal Antibody (E-AB-18525)
For research use only.
| Verified Samples |
Verified Samples in IHC: Human liver cancer, Human esophagus cancer |
| Dilution | IHC 1:50-1:300 |
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human |
| Applications | IHC |
| Clonality | Polyclonal |
| Immunogen | Fusion protein of human ATXN3 |
| Abbre | ATXN3 |
| Synonyms | AT3, ATX3, ATXN3, Ataxin 3, Ataxin-3, EC 3.4.22., JOS, Josephin, Mac, Machado Joseph disease, Machado Joseph disease (spinocerebellar ataxia 3, ataxin 3 variant h, ataxin 3 variant m, ataxin 3 variant ref, ataxin 3), autosomal dominant, olivopontocerebellar ataxia 3 |
| Swissprot | |
| Cellular Localization | Nucleus matrix. Predominantly nuclear, but not exclusively, inner nuclear matrix. |
| Concentration | 0.7 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Antigen affinity purification |
| Research Areas | Cancer, Epigenetics and Nuclear Signaling, Neuroscience |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
| background | Machado-Joseph disease, also known as spinocerebellar ataxia-3, is an autosomal dominant neurologic disorder. The protein encoded by this gene contains (CAG)n repeats in the coding region, and the expansion of these repeats from the normal 12-44 to 52-86 is one cause of Machado-Joseph disease. There is a negative correlation between the age of onset and CAG repeat numbers. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. |
Other Clones
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