ASAH2 Polyclonal Antibody (E-AB-14747)
For research use only.
| Verified Samples |
Verified Samples in WB: LoVo, Mouse heart Verified Samples in IHC: Human brain, Human colon cancer |
| Dilution | WB 1:200-1:1000, IHC 1:25-1:100 |
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC |
| Clonality | Polyclonal |
| Immunogen | Recombinant protein of human ASAH2 |
| Abbre | ASAH2 |
| Synonyms | AI585898, ASAH2, Acylsphingosine deacylase 2, BCDase, HNAC1, LCDase, MGC129777, N CDase, N acylsphingosine amidohydrolase (non lysosomal ceramidase) 2, N acylsphingosine amidohydrolase 2, N-CDase, N-acylsphingosine amidohydrolase 2, hCD, mitochondrial ceramidase |
| Swissprot | |
| Calculated MW | 86 kDa |
| Cellular Localization | Cell membrane. The neutral ceramidase soluble form is a secreted protein. According to PubMed:10781606, it is mitochondrial. However, they used a shorter form in its N-terminus, which may explain this localization which probably does not exist in vivo. |
| Concentration | 0.7 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Cancer, Metabolism, Signal Transduction |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
| background | Ceramidases (EC 3.5.1.23), such as ASAH2, catalyze hydrolysis of the N-acyl linkage of ceramide, a second messenger in a variety of cellular events, to produce sphingosine. Sphingosine exerts both mitogenic and apoptosis-inducing activities, and its phosphorylated form functions as an intra- and intercellular second messenger. |
Other Clones
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Other Formats
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Unconjugated
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