APPL1 Polyclonal Antibody (E-AB-10172)
For research use only.
| Verified Samples |
Verified Samples in WB: A172 Verified Samples in IHC: Human esophagus cancer, Human lung cancer |
| Dilution | WB 1:500-1:2000, IHC 1:100-1:300 |
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Applications | WB, IHC |
| Clonality | Polyclonal |
| Immunogen | Recombinant protein of human APPL1 |
| Abbre | APPL1 |
| Synonyms | Adapter protein containing PH domain, Adaptor Protein Containing pH Domain, Adaptor protein containing pH domain PTB domain and leucine zipper motif, Adaptor protein containing pH domain PTB domain and leucine zipper motif 1, Adaptor protein phosphotyrosine i |
| Swissprot | |
| Calculated MW | 80 kDa |
| Cellular Localization | Early endosome membrane. Nucleus. Early endosomal membrane-bound and nuclear. Translocated into the nucleus upon release from endosomal membranes following internalization of EGF. |
| Concentration | 0.1 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Cancer, Cell Biology, Developmental Biology, Neuroscience, Signal Transduction |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
| background | The protein encoded by this gene has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. The encoded protein binds many other proteins, including RAB5A, DCC, AKT2, PIK3CA, adiponectin receptors, and proteins of the NuRD/MeCP1 complex. This protein is found associated with endosomal membranes, but can be released by EGF and translocated to the nucleus. |
Other Clones
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Other Formats
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Unconjugated
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