Add to cart
For research use only.
Alternate Names | B7H1PD-L1PDCD1L1PDCD1LG1PDL1, B7 homolog 1, B7-H, B7-H1, Programmed cell death ligand 1 |
Clone No | |
Leadtime | Order now, ship in 3 days |
Background | CD274, also known as PD-L1 and B7-H1, is type I transmembrane glycoprotein that serves as a ligand for CD279 (PD-1). This interaction is believed to regulate the balance between the stimulatory and inhibitory signals needed for responses to microbes and maintenance of self-tolerance. CD274 is involved in the costimulation of T cell proliferation and IL-10 and IFN-γ production in an IL-2-dependent and CD279-independent manner. Conflicting data has shown that CD274 can inhibit T cell proliferation and cytokine production, and alternatively, enhance T cell activation. Other studies suggest that CD274 may signal bidirectionally, raising interesting implications for its expression in a wide variety of cell types, including T and B cells, antigen-presenting cells, and nonhematopoietic cells. |
Abbre | PD-L1 |
Swissprot | |
Host | Mouse |
Reactivity | Human |
Clonality | Monoclonal |
Isotype | Mouse IgG2b, κ |
Isotype Control | E-AB-F09812E |
Applications | FCM |
Research Areas | Cancer Biomarkers;Costimulatory Molecules;Immunology |
Cellular Localization | Membrane |
Form | Liquid |
Concentration | 5 μL/Test |
Conjugation | APC |
Conjugation Information | APC is designed to be excited by the Red (627-640 nm) laser and detected using an optical filter centered near 660 nm (e.g., a 660/20 nm bandpass filter). |
Spectrum | |
Storage Buffer | Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant. |
Storage | This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze. |
Expiration Date | 12 months |
Shipping | Ice bag |
Other Clones
1 Results
Other Formats
1 Results
APC
Biotin
Elab Fluor®700
FITC
None (AF/LE)
PE
PE/Cyanine 5
PE/Cyanine 7
PerCP/Cyanine 5.5
Unconjugated