Angiotensin Converting Enzyme 1 (ACE1) Inhibitor Screening Kit (E-BC-D016)
For research use only.
| Detection Principle |
Angiotensin Converting Enzyme 1(ACE1), also known as angiotensin converting enzyme (ACE), kininase II, and peptidy-carboxylpeptidase, is an important component of the renin-angiotensin system (RAS). In the RAS system, angiotensin is converted into angiotensin II. Angiotensin II can cause strong contractions of vascular smooth muscle, increasing peripheral vascular resistance and thereby leading to elevated blood pressure. Excessively high ACE1 activity can directly result in elevated blood pressure. ACE1 inhibitors can achieve the purpose of lowering blood pressure by inhibiting ACE1 activity. The detection principle of this kit: ACE1 catalyzes the decomposition of the substrate, releasing fluorescent products. After adding the inhibitor, the generation of fluorescent substances will be inhibited, and the effect of the inhibitor is determined based on the degree of inhibition. |
| Sample Type | Inhibitor |
| Detection Method | Fluorometric method |
| Detection Instrument | Fluorescence microplate reader (Ex/Em=320 nm/420 nm) |
| Research Area | Inhibitor Screening |
| Storage | This product can be stored at -20°C for 12 months with shading light. |
| Valid Period | 12 months |
| Precision | inter-assay CV: 0.3-9.2% | intra-assay CV: 0.2-3.3% |
| Sample Volume | 10 μL |
| Assay Time | 50 min |
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