AF/LE Purified Anti-Mouse CD22 Antibody[Cy34.1] (E-AB-F10210)
For research use only.
| Alternate Names | Siglec2, B-cell receptor CD22, B-lymphocyte cell adhesion molecule, BL-CAM, CD22, Cd22, Lyb-8, Sialic acid-binding Ig-like lectin 2, Siglec-2, T-cell surface antigen Leu-14 |
| Clone No | |
| Leadtime | Order now, ship in 3 days |
| Background | The Cy34.1 monoclonal antibody specifically binds to the B-lymphocyte differentiation antigen CD22 on strains having the Lyb-8.2 alloantigen (e.g., A, BALB/c, CBA, C3H/He, C57BL, C57L, C58, SJL, SWR, but not AKR, DBA/1, DBA/2, NZB, PL). CD22 is expressed at high levels on mature peripheral B lymphocytes (follicular and marginal zone), B-1 cells (CD5+ B cells), and plasma cells. It is a member of the Ig gene superfamily and associates with the B-cell antigen receptor. Its sialic acid- binding immunoglobulin-like lectin (siglec) extracellular region mediates B-cell adhesion to ligands on endothelial cells in the bone marrow. Its intracellular domain is phosphorylated after cross-linking of antigen receptor or MHC class II antigen. It is involved in negative regulation of B-cell activation and protection from autoimmunity. B-cell proliferative responses to LPS or anti-mouse Ig µ chain are augmented in the presence of Cy34.1 mAb. |
| Abbre | CD22 |
| Swissprot | |
| Host | Mouse |
| Reactivity | Mouse |
| Clonality | Monoclonal |
| Isotype | Mouse IgG1, κ |
| Applications |
FCM
|
| Research Areas | Immunology |
| Concentration |
≥ 1 mg/mL
|
| Conjugation | None (AF/LE) |
| Storage Buffer | Sterile PBS, pH 7.2. < 1.0 EU per mg of the antibody as determined by the LAL method. |
| Storage | Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions. |
| Expiration Date | 12 months |
| Shipping | Ice bag |
Other Clones
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Other Formats
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APC
Biotin
Elab Fluor®488
Elab Fluor®647
Elab Fluor®700
Elab Fluor®Violet 450
FITC
None (AF/LE)
PE
PE/Cyanine 5
PE/Cyanine 5.5
PE/Cyanine 7
PerCP/Cyanine 5.5
Unconjugated
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