3-Hydroxy-3-methylglutaryl-CoA Reductase (HMGR) Inhibitor Screening Kit (E-BC-D011)
For research use only.
| Detection Principle |
3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) is the rate-limiting enzyme of mevalonate pathway, which is the metabolic pathway of acetyl-CoA to produce cholesterol.This detection kit can screen inhibitors of HMGR, which is an important tool for basic research of cholesterol and other related metabolic pathways. The detection principle of this kit: HMGR catalyzed substrate reaction consumes NADPH, and the absorbance decreases at 340 nm. The addition of inhibitors will inhibit HMGR enzyme activity, resulting in a decrease in the rate of absorbance decline. The inhibition rate can be calculated by measuring the change value of absorbance. |
| Sample Type | Inhibitor |
| Detection Method | Colorimetric method |
| Detection Instrument | Microplate reader (330-350 nm, optimum wavelength: 340 nm) |
| Research Area | Glycolysis And Lipid Metabolism , Inhibitor Screening |
| Other Reagents Required | DMSO |
| Storage | This product can be stored at -20°C for 12 months with shading light. |
| Valid Period | 12 months |
| Precision | inter-assay CV: 2.2-10.0% | intra-assay CV: 1.8-3.3% |
| Sample Volume | 20 μL |
| Assay Time | 40 min |
Other Clones
{{antibodyDetailsPage.numTotal}} Results
-
{{item.title}}
Citations ({{item.publications_count}}) Manual MSDS
Cat.No.：{{item.cat}}
{{index}} {{goods_show_value}}
Other Formats
{{formatDetailsPage.numTotal}} Results
-
{{item.title}}
Citations ({{item.publications_count}}) Manual MSDS
Cat.No.：{{item.cat}}
{{index}} {{goods_show_value}}
-
IF：{{item.impact}}
Journal：{{item.journal}} ({{item.year}})
DOI：{{item.doi}}Reactivity：{{item.species}}
Sample Type：{{item.organization}}
-
Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}}
