CDK6 Polyclonal Antibody (E-AB-66778)
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For research use only.
| Verified Samples |
Verified Samples in IHC: Rat liver, Human colon carcinoma, Human breast cancer, Mouse liver, Mouse brain Verified Samples in IF: H9C2, L929, U-2OS, Mouse brain |
| Dilution | IHC 1:50-1:200, IF 1:50-1:200 |
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Applications | IHC, IF |
| Clonality | Polyclonal |
| Immunogen | Recombinant fusion protein of human CDK6 (NP_001250.1). |
| Abbre | CDK6 |
| Synonyms | CDK6, MCPH12, PLSTIRE |
| Swissprot | |
| Cellular Localization | Cytoskeleton, centrosome, Cytosol, Nucleus, nucleoplasm, nucleus, Other locations: cyclin-dependent protein kinase holoenzyme complex, cytoplasm, ruffle. |
| Concentration | 1 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Cancer, Cell Biology, Epigenetics and Nuclear Signaling |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
| background | The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. Expression of this gene is up-regulated in some types of cancer. Multiple alternatively spliced variants, encoding the same protein, have been identified. |
Other Clones
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Other Formats
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Unconjugated
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